There are plenty of desktop clients for tweeter that allows you to manage your tweets & replies. One more such client is tweetdeck created by louis gray. This application is free & in beta so expect more features soon.Get it from http://tweetdeck.com
Tweetdeck is adobe AIR application for Twitter that allows you group,filter & search incoming tweets for you.

Features
Tweetdeck allows you to arrange replies in columns, you can even search your tweets from search function (this feature of summize is now part of twitter officially). You can define upto 10 different columns.
Status messages can be seen at the bottom right of the client, you can see “Rate limit exceeded” etc type of messages. At the left corner,you’ll see the message that
Columns & Groups
Other than above mentioned features, there is
It is written in

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